Iron-catalyzed direct arylation of benzenes
Charette et al. have reported iron-catalyzed direct arylation of benzenes and arenes with aryl iodides. The reaction is also applicable to synthesis of heterobiaryls with use of pyridyl and pyrazyl iodides. The catalytic system is composed of Fe(OAc)₂ and bathophenanthroline as a ligand. Mechanistic evidence suggests that the transformation proceeds through a Fe-catalyzed aryl living radical pathway. They demonstrated that the purity of the Fe(OAc)₂ did not play a crucial role in the success of the reaction.
F. Vallée, J. J. Mousseau. A. B. Charette, J. Am. Chem. Soc. 2010, 132, 1514.
       ------------------------------------------
The new TCI catalog "Fine Chemicals 2010-2011" is available now!
The catalog includes more than 21,000 high quality chemicals - including 1,300+ new items.
Request your free copy!

       ------------------------------------------
The new "Reagent Guide Bioscience & Analytical Science" is now available.
It contains reagents which are mainly used in the field of Bioscience and Analytical Science.
Reserve your free copy now!!
       ------------------------------------------
New HPLC column is now available -
"TCI Dual ODS-CX15"
Enables rapid analysis of both basic and hydrophobic compounds simultaneously!

Details